RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Ccn2
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Microarray Analysis etc.
Target
NA
Pathway
NA
PubMed ID
Title
Inhibition of nuclear factor kappaB in the lungs protect bleomycin-induced lung fibrosis in mice
Year
2022
Function
"The mRNA expression of several fibrotic genes, Col1A1, CTGF, MMP2, Acta2 and TGFbeta1 was increased by 3.15 +- 0.83-, 1.74 +- 0.24-, 2.3 +- 0.19-, 1.91 +- 0.36 and 3.44 +- 0.39 (P < 0.05)-fold, respectively, in lungs of BLM-treated WT mice, compared with the untreated WT mice."